Abstract
A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC(50)=22 approximately 70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers.
MeSH terms
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Bacterial Proteins / antagonists & inhibitors*
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Bacterial Proteins / metabolism
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology*
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Peptide Synthases / antagonists & inhibitors*
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Peptide Synthases / metabolism
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Peptidoglycan / biosynthesis
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Structure-Activity Relationship
Substances
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Bacterial Proteins
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Enzyme Inhibitors
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Peptidoglycan
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Peptide Synthases
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UDP-N-acetylmuramoylalanyl-D-glutamyllysine-D-alanyl-D-alanine ligase